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  • Chemical Genetics
    a powerful approach that overcomes these limitations by the use of small molecules that perturb the protein function in a specific fast and conditional manner The function of redundant proteins can be simultaneously perturbed by a general antagonist thereby revealing novel phenotypes Additionally embryonic lethality due to interference with essential signaling components can be avoided by modulation of the dosage of the chemical compounds or by treatment at a later developmental stage The main objective of this research is to identify a large set of small chemicals affecting endomembrane trafficking of different plasma membrane proteins by effectively blocking and accumulating these cargos in different endomembrane compartments Selected publications Mishev K Dejonghe W Russinova E 2013 Small molecules for dissecting endomembrane trafficking a cross systems view Chem Biol 20 475 486 Drakakaki G Robert S Szatmari AM Brown MQ Nagawa S Van Damme D Leonard M Yang Z Girke T Schmid SL Russinova E Friml J Raikhel NV Hicks GR 2011 Clusters of bioactive compounds target dynamic endomembrane networks in vivo Proc Natl Acad Sci U S A 108 17850 17855 De Rybel B Audenaert D Vert G Rozhon W Mayerhofer J Peelman F Coutuer S Denayer T Jansen L Nguyen L Vanhoutte I Beemster GT Vleminckx K Jonak C Chory J Inzé D Russinova E Beeckman T 2009 Chemical inhibition of a subset of Arabidopsis thaliana GSK3 like kinases activates brassinosteroid signaling Chem Biol 16 594 604 Prev Next Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/272-chemical-genetics (2016-04-26)
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  • International Projects
    Admin Brassinosteroids Jenny Russinova International Projects An overview of the international projects we are or were involved in 2008 2012 BRAVISSIMO BRAVISSIMO BRAssinosteroid Venture Increasing StudentS International MObility was a project funded by the European Commission as part of its Seventh Framework Programme for Research and Technological Development The project started in September 2008 and it run over a period of four years The aim of this project was to gain conceptual advance into the function of plant steroid hormones brassinosteroids in Arabidopsis thaliana and to translate this understanding into model crop plants Prev Next Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab Tom Beeckman Lab Yves Van de Peer Lab Wout Boerjan Lab About PSB PSB Missions The Department Infrastructure Core Facilities International Projects Publications News Seminars Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/269-international-projects (2016-04-26)
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  • News
    Prev Next Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab Tom Beeckman Lab

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/271-news (2016-04-26)
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  • Joining the Lab
    apply for independent fellowships Prev Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/273-joining-the-lab (2016-04-26)
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  • Lieven De Veylder
    9052 Gent BELGIUM Fax 32 0 9 33 13 809 Projects Lieven De Veylder Group Members Publications Lieven De Veylder Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab

    Original URL path: http://www.psb.vib-ugent.be/lieven-de-veylder (2016-04-26)
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  • Group Members
    Lieven De Veylder Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab Tom Beeckman Lab Yves Van de Peer Lab Wout Boerjan Lab About PSB PSB Missions The Department

    Original URL path: http://www.psb.vib-ugent.be/group-members-livey (2016-04-26)
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  • Introduction
    of the cell cycle is of crucial importance during the development of all multi cellular organisms Although for all organisms it is the goal to divide only if the DNA has been replicated correctly and without damage years of research have revealed many differences between the ways animals and plants control their cell cycle The group aims to understand how cell cycle control genes drive plant cell proliferation and to elucidate how cell division control interacts with different aspects of plant development such as morphogenesis architecture and growth both under control and stress conditions Identifying the underlying mechanisms that control cell division might open opportunities to adjust plant size yield and architecture Next Projects Lieven De Veylder Group Members Publications Lieven De Veylder Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab Tom Beeckman Lab Yves Van de Peer Lab Wout Boerjan Lab About PSB PSB Missions The Department Infrastructure Core Facilities International Projects Publications News Seminars Research Groups

    Original URL path: http://www.psb.vib-ugent.be/cell-cycle/277-introduction (2016-04-26)
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  • Mitosis or Endoreduplication
    cycle we use the root tip and the first developing leaf pair of Arabidopsis thaliana as a model system In both model systems cells gradually exit the mitotic cell cycle and engage into an endocycle Our molecular analyses indicate that the onset of endoreplication is controlled through a robust network including the involvement of positive and negative feedback mechanisms Currently we use key regulators of this network to perturb endocycle onset in a tissue and cell specific manner followed by a comprehensive analysis of the effects on plant growth under control and stress conditions Central to this work is the development of a three dimensional endoploidy cartogram of the complete root and leaf The results of this project may eventually result in the development of new strategies to cope with yield losses induced by environmental stresses Tissue specific modification of endoploidy affecting leaf morphogenesis Publications Polyn S Willems A and De Veylder L 2015 Cell cycle entry maintenance and exit during plant development Curr Opin Plant Biol 23 1 7 De Veylder L Larkin J C and Schnittger A 2011 Molecular control and function of endoreduplication in development and physiology Trends Plant Sci 16 624 364 Heyman J Van den Daele H De Wit K Boudolf V Berckmans B Verkest A Kamei C L A De Jaeger G Koncz C and De Veylder L 2011 The Arabidopsis thaliana ULTRAVIOLET B INSENSITIVE 4 protein maintains cell division activity by temporal inhibition of the anaphase promoting complex cyclosome Plant Cell 23 4394 4410 Radziejwoski A Vlieghe K Lammens T Berckmans B Maes S Jansen M Knappe C Albert A Seidlitz H K Bahnweg G Inzé D Cools and De Veylder L 2011 Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset EMBO J 30 355 363 Gaamouche T Manes C

    Original URL path: http://www.psb.vib-ugent.be/cell-cycle/278-mitosis-or-endoreduplication (2016-04-26)
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