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  • Phosphoproteomics
    confirm the importance of key differentially phosphorylated proteins ideally hubs controlling major switches in physiological and developmental processes in a biological process candidates are functionally characterized using kinase assays and phospho specific antibodies to demonstrate functionality and in vivo phosphorylation respectively complemented with loss and gain of function approaches including site directed phospho site mutagenesis and detailed analyses of expression patterns both in Arabidopsis and monocot crops when relevant Recommended Reading Hengeveld R C Hertz N T Vromans M J Zhang C Burlingame A L Shokat K M Lens S M 2012 Development of a chemical genetic approach for human Aurora B kinase identifies novel substrates of the chromosomal passenger complex Mol Cell Proteomics 11 47 59 Kline K G Barrett Wilt G A Sussman M R 2010 In planta changes in protein phosphorylation induced by the plant hormone abscisic acid Proc Natl Acad Sci USA 107 15986 15991 Blethrow J D Glavy J S Morgan D O Shokat K M 2008 Covalent capture of kinase specific phosphopeptides reveals Cdk1 cyclin B substrates Proc Natl Acad Sci USA 105 1442 1447 Prev Projects Ive De Smet Group Members Publications Ive De Smet Research Groups Alain Goossens Lab Ann Depicker Lab

    Original URL path: http://www.psb.vib-ugent.be/functional-phosphoproteomics/265-phosphoproteomics (2016-04-26)
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  • Jenny Russinova
    Fax 32 0 9 33 13 809 Prev Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab

    Original URL path: http://www.psb.vib-ugent.be/jenny-russinova (2016-04-26)
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  • Group Members
    Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab Tom Beeckman Lab Yves Van de Peer Lab Wout Boerjan Lab About PSB PSB

    Original URL path: http://www.psb.vib-ugent.be/group-members-eurus (2016-04-26)
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  • Lab Members and Alumni
    Bacterial Genetics and Physiology Lab LGPB under supervision of Dr Laurence Van Melderen where he investigated the use of E coli toxin antitoxin systems for gene containment in transgenic plants In January 2014 he started his PhD research in the lab of Dr Jenny Russinova working on the signal integration and specificity in brassinosteroid signalling in Arabidopsis thaliana Xiuyang Zhao Predoctoral fellow Xiuyang obtained a Master Degree in Cell Biology at Lanzhou University P R China in 2015 He did his thesis at the Key Laboratory of Cell Activities and Stress Adaptations Ministry of Education P R China under supervision of Dr Zheng Guochang Academician of Chinese Academy of Science where he investigated the role of a novel ribonucleoprotein in the network of microRNAs and the stress tolerance in Arabidopsis thaliana In September 2015 he started his PhD research in the lab of Dr Jenny Russinova working on endocytic regulation of brassinosteroid signaling in Arabidopsis thaliana Qing Lu Predoctoral fellow Qing obtained his Master degree in Bioengineering at Shandong University China in 2015 under the supervision of Prof Xiang Fengning His thesis was focus on the functional analysis of microRNA in brassinosteroid signaling in Arabidopsis thaliana In September 2015 he obtained a CSC grant and started his PhD research in the lab of Dr Jenny Russinova working on small molecule dissection of brassinosteroid signaling in Arabidopsis thaliana Guilherme Pereira de Oliveira Predoctoral fellow Guilherme obtained a Master degree in Sciences Plant Physiology and Biochemistry at the University of Sao Paulo Escola Superior de Agricultura Luiz de Queiroz Brazil under the supervision of Dr Lázaro E P Peres His thesis was focused in the correlation between genes affecting leaf shape and in vitro regeneration capacity in tomato In October 2015 he obtained CNPq grant and started his PhD research in the lab of Dr Jenny Russinova Guilherme obtained a Master degree in Sciences Plant Physiology and Biochemistry at the University of Sao Paulo Escola Superior de Agricultura Luiz de Queiroz Brazil under the supervision of Dr Lázaro E P Peres His thesis was focused in the correlation between genes affecting leaf shape and in vitro regeneration capacity in tomato In October 2015 he obtained CNPq grant and started his PhD research in the lab of Dr Jenny Russinova Technical Staff Isabelle Vanhoutte Lab manager Isabelle obtained her B Sc in Pharmaceutical and Biological techniques in1997 at KaHo St Lieven in Gent She graduated in 1999 from the Larenstein International Agricultural College Velp Netherlands as Industrial engineer in Laboratory Science with specialisation in Plant Biotechnology She worked for 2 years at Bayer Cropscience in the area of molecular assisted breeding of oilseed rape before joining the VIB in 2001 At the VIB she first joined the group of Prof G Gheysen mainly doing whole mount RNA in situ hybridisation of plant parasitic nematodes After 2 years she joined another group to check the presence of previously selected cDNA AFLP tags in 50 000 genes of a MJM treated BY2 cDNA library under

    Original URL path: http://www.psb.vib-ugent.be/lab-members-and-alumni-eurus (2016-04-26)
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  • Group in Action
    in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova Lab Lieven De Veylder Lab Mieke Van Lijsebettens Lab Moritz Nowack Lab Sofie Goormachtig Lab Steven Maere Lab Tom Beeckman Lab Yves Van de Peer Lab Wout Boerjan Lab About PSB PSB Missions

    Original URL path: http://www.psb.vib-ugent.be/group-in-action-eurus (2016-04-26)
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  • Introduction
    regulate photomorphogenesis etiolation and cell expansion Brassinosteroids have a broad spectrum of activities that have a positive effect on the quantity and quality of crops and they increase plant resistance to stress and pathogens The brassinosteroid pathway is one of the best defined signal transduction pathways in plants In Arabidopsis brassinosteroids are perceived by receptor kinases that transduce the signal from the cell surface to the nucleus by an intracellular cascade of phosphorylation mediated protein protein interactions involving kinases phosphatases 14 3 3 proteins and nuclear transcription factors In addition brassinosteroid signaling is regulated by the plant endocytic machinery because an increased endosomal localization of the brassinosteroid receptor enhances the signaling The main objective of the group is to combine genetic molecular and cell biology tools to study the mechanism of brassinosteroid signaling regulation in plants One aspect of the research is to understand the subcellular compartmentalization and trafficking of brassinosteroid receptor complexes and their relevance to brassinosteroids physiological responses We use chemical genomics and proteomics to investigate the subcellular localization mobility transport routes and binding interactions of different brassinosteroid signaling components In addition we want to position important downstream brassinosteroid signaling regulators such as the Arabidopsis GSK3 like kinases in subcellular compartments important for brassinosteroid receptor activity The potential application of brassinosteroids in agriculture is based not only on their ability to increase crop yields but also on the fact that they increase resistance to different stress conditions such as high salinity drought and fungal and viral infections Thus unraveling the regulatory mechanisms of brassinosteroid signaling on the level of signaling components brassinosteroid target genes and endomembrane trafficking regulators or identifying chemicals that modulate any of those components can be used to develop selective strategies for high yielding plants Next Projects Jenny Russinova Group Members Lab Members and Alumni

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/267-introduction (2016-04-26)
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  • Integration and Specificity of Brassinosteroid Signaling
    factor SPEECHLESS SPCH both components of the ERECTA ER signaling pathway that regulates stomatal development BIN2 directly interacts with the transcriptional repressor ARF2 and provides a mechanistic explanation for the crosstalk between brassinosteroids and auxin Brassinosteroid signaling is also highly integrated with the light and gibberellin pathways through the direct interactions BZR1 PIF4 and BZR1 DELLA The aim of the project is to combine genetics proteomics and molecular cell biology to study the mechanisms of brassinosteroid signaling interaction at the level of BIN2 to eventually answer the question how specificity is achieved in brassinosteroid signaling Selected publications Gudesblat GE Betti C Russinova E 2012 Brassinosteroids tailor stomatal production to different environments Trends Plant Sci 17 685 687 Gudesblat GE Schneider Pizon J Betti C Mayerhofer J Vanhoutte I van Dongen W Boeren S Zhiponova M de Vries S Jonak C Russinova E 2012 SPEECHLESS integrates brassinosteroid and stomata signalling pathways Nat Cell Biol 14 548 554 Prev Next Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/268-integration-and-specificity-of-brassinosteroid-signaling (2016-04-26)
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  • Endocytosis and Brassinosteroid Signaling
    we are far from a complete understanding of the endocytic trafficking of receptor complexes and to which extent their signaling activity requires and is modulated by these routes The project aims at filling this gap by gaining basic knowledge of the relationship between the endocytic transport and signaling activity of brassinosteroid hormones In addition the discovery of novel plant endocytic and signaling scaffolds would give us an evolutionary insight into why certain gene families expanded in plants while others range from being absent to having been maintained at an ancestral minimum Selected publications Di Rubbo S Irani NG Kim SY Xu ZY Gadeyne A Dejonghe W Vanhoutte I Persiau G Eeckhout D Simon S Song K Kleine Vehn J Friml J De Jaeger G Van Damme D Hwang I Russinova E 2013 The clathrin adaptor complex AP 2 mediates endocytosis of brassinosteroid insensitive1 in Arabidopsis Plant Cell 25 2986 2997 Irani NG Di Rubbo S Mylle E Van den Begin J Schneider Pizo J Hniliková J Šíša M Buyst D Vilarrasa Blasi J Szatmári AM Van Damme D Mishev K Codreanu MC Kohout L Strnad M Caño Delgado AI Friml J Madder A Russinova E 2012 Fluorescent castasterone reveals BRI1 signaling from the plasma membrane Nat Chem Biol 8 583 589 Di Rubbo S Irani NG Russinova E 2011 PP2A phosphatases the on off regulatory switches of brassinosteroid signaling Sci Signal 4 pe25 Irani NG Russinova E 2009 Receptor endocytosis and signaling in plants Curr Opin Plant Biol 12 653 659 Prev Next Projects Jenny Russinova Group Members Lab Members and Alumni Group in Action Publications Jenny Russinova Research Groups Alain Goossens Lab Ann Depicker Lab Bruno Cammue Lab Daniel Van Damme Lab Dirk Inzé Lab Frank Van Breusegem Lab Geert De Jaeger Lab Ive De Smet Lab Jenny Russinova

    Original URL path: http://www.psb.vib-ugent.be/brassinosteroids/270-endocytosis-and-brassinosteroid-signaling (2016-04-26)
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